Serious long-term side effects caused by intensive radiochemotherapy emphasize the need for novel treatment approaches with reduced toxicity. 6 Despite these molecular insights, high-risk NB remains a major challenge in pediatric oncology. Amplification of the MYCN gene, which encodes for the oncogenic transcription factor MYCN (also known as N-Myc), was the first genomic aberration found to be associated with poor prognosis. Activation of telomere maintenance mechanisms characterizes high-risk NB, 1 and additional alterations in the p53 or RAS pathway, known to play a role in NB pathogenesis, 2–5 further worsen disease outcome. Neuroblastoma (NB) is an extracranial solid tumor of early childhood that originates from the developing sympathetic nervous system.
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